Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia
نویسندگان
چکیده
منابع مشابه
Mitochondrial Variants in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder
BACKGROUND Mitochondria provide most of the energy for brain cells by the process of oxidative phosphorylation. Mitochondrial abnormalities and deficiencies in oxidative phosphorylation have been reported in individuals with schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) in transcriptomic, proteomic, and metabolomic studies. Several mutations in mitochondrial DNA...
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BACKGROUND Mitochondrial dysfunction was reported in schizophrenia, bipolar disorderand major depression. The present study investigated whether mitochondrial complex I abnormalities show disease-specific characteristics. METHODOLOGY/PRINCIPAL FINDINGS mRNA and protein levels of complex I subunits NDUFV1, NDUFV2 and NADUFS1, were assessed in striatal and lateral cerebellar hemisphere postmort...
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PURPOSE OF REVIEW This article reviews the recent literature on reward processing dysfunction in major depression (MDD), bipolar disorder and schizophrenia, with a focus on approach motivation, reward learning and reward-based decision-making. RECENT FINDINGS Emerging evidence indicates the presence of reward processing abnormalities across all three disorders, supporting a transdiagnostic ap...
متن کاملMemory Impairment in Patients With Schizophrenia and Bipolar Disorder With and Without Psychosis: A Comparative Study
Background: Cognitive impairment is a common symptom in both Schizophrenia (SZ) and Bipolar Disorder (BD), and studies have demonstrated memory impairment in patients with these disorders. Objectives: To compare memory impairment in patients with SZ, BD with psychosis, and BD without psychosis. Materials & Methods: This study was a cross-sectional study conducted on 42 patients referred to Sh...
متن کاملNeurobiological basis of bipolar disorder: Mitochondrial dysfunction hypothesis and beyond
Bipolar disorder is one of two major psychotic disorders together with schizophrenia and causes severe psychosocial disturbance. Lack of adequate animal models hampers development of new mood stabilizers. We proposed a mitochondrial dysfunction hypothesis and have been studying the neurobiology of bipolar disorder based on this hypothesis. We showed that deletions of mitochondrial DNA (ΔmtDNA) ...
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ژورنال
عنوان ژورنال: International Journal of Developmental Neuroscience
سال: 2010
ISSN: 0736-5748,1873-474X
DOI: 10.1016/j.ijdevneu.2010.08.007